The skin permeation of antibacterial agent, bacitracin zinc, in liposomes and niosomes, after topical application, were elucidated in the present study with aimed to increase its penetration capacity hence efficiency. The formulations of bacitracin zinc were prepared and characterized for vesicle size, entrapment efficiency, and drug permeation across rat skin and were evaluated for their stability. Formulation with niosomes demonstrated a better skin permeation potential, sustained release characteristics and higher stability as compared to liposomes. The ability of liposomes and niosomes to modulate drug delivery makes the two vesicles useful to formulate topical bacitracin zinc.
Bacitracin zinc, Liposomes, Niosomes, Skin permeation
