Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues

As series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline 6a-o derivatives were synthesized and tested for Antihyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. All the newly synthesized compounds chemical structures were confirmed by IR, ¹H-NMR, mass spectroscopy and elemental analyses. The results of studies indicate that the compounds 6a, b, d, j, o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.