Development of Granisetron Hydrochloride Fast Dissolving Tablets: Comparative Evaluation of Superdisintegrating Agents

The purpose of study was development of fast dissolving Granisetron Hydrochloride (GRA) tablets using suitable disintegrating agent. Comparative effect of incorporation of superdisntegrants and conventional disintegrant at same concentrations, on disintegration and dissolution was studied. The superdisintegrants used were sodium starch glycolate (SSG) and Kyron^® T-314 (Polacrillin potassium) while sodium alginate (SA) was used as representative conventional disintegrant. The tablets were prepared by wet granulation method. The disintegration times were lower and dissolution profile of GRA was comaparatively better with the batches containing SSG compared to other disintegrating agents. The granisetron tablets with 3% SSG shows lower disintegration time than Kyron^® T-314 and SA.