Visible Spectrophotometric Methods for Determination of Olanzapine from Tablet Formulation

Two simple and sensitive visible spectrophotometric methods have been developed for the determination of Olanzapine form Pharmaceutical tablet dosage form. Developed methods are based on formation of chloroform extractable ion pair colored complex of drug with Cosneasie Brilliant Blue R (Method A) and Methyl orange (Method B). The extracted complex formed in method A and B showed absorbance maxima at 596.0 nm and 411.0 nm and linearity was observed in concentration range of 25–150 μgm/ml and 0–250 μgm/ml of olanzapine respectively. The results of analysis were validated statistically and by recovery studies.