*Corresponding Author E-mail: sunakar_bu@yahoo.co.in
Substituted indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide, benzaldehyde and furfualdehyde. Inclusion complexes of these compounds with β-cyclodextrin have been prepared so as to increase their solubility and bioaccessibility. The stability of inclusion complexes have been studied by the determination of thermodynamic parameters like change in free energy, change in enthalpy, change in entropy and stability constant which clearly suggests that the formation of inclusion complex is thermodynamically allowed. On screening the compounds and their inclusion complexes for antibacterial activity and antioxidant activity, it is found that these activities increase significantly after inclusion complex formation.
Substitutedindole, β-Cyclodextrin, Inclusion complex, antimicrobial activity
