Formulation, Characterization and In Vitro Evaluation of Mucoadhesive Microspheres of Clarithromycin and Omeprazole

The objective of the present investigation was to formulate and evaluate the mucoadhesive microsphere of clarithromycin and omeprazole using hydroxyl propyl methyl cellulose K4M, hydroxyl propyl methyl cellulose K100M and carbopol 971p. Microspheres were prepared by non-aqueous emulsification solvent evaporation method using liquid paraffin as a cross linking agent. The prepared microspheres were evaluated for micromeritic properties. Batch CF5 and OF5 shows the highest adhesion property i.e. 08 hrs and 7.55 hrs respectively. Likewise batch CF5 and OF5 also shows highest % drug entrapment i.e. 82% and 96.26% respectively and declared as an optimized batches. These batches were filled in 0 size capsules and evaluated for weight variation, content uniformity and % cumulative drug release.