Aegle marmelos Fruit Extract Prevents Cyclophosphamide Induced Micronucleus Formation in Mice

The aim of the present study was to investigate the protective efficacy of hydromethanolic fruit extract of Aegle marmelos on Cyclophosphamide (CP) induced micronuclei (MN) formation in bone marrow cells of mice. Swiss albino mice were treated with a single i.p. dose of 450, 675 and 900 mg/kg b.w. with Aegle marmelos fruit extract prior to CP administration. The result demonstrated that the micronuclei frequencies gradually decreased with increase in concentration of the extract suggesting a protective effect and the extract alone had not induced MN formation, reiterating the fact that the extract has no pro-mutagenic components.