Pharmacological Investigation of Anticonvulsant Activity of Sesamum indicum Linn. 50% Ethanol Leaves Extract

The anticonvulsant activity of 50% ethanol leave extract of Sesamum indicum (ESI) were investigated on various animal models including Strychnine nitrate (SN) induced seizure, Pentylenetetrazole (PTZ) induced seizure, Maximal electroshock seizure model in mice.ESI (100 and 200 mg/kg) produce dose dependent and Significant (P<0.05) increases in onset to clonic and tonic convulsions and at 400 mg/kg showed complete protection against seizure induced by strychnine but not with pentylenetetrazole. 50% ethanol extract of Sesamum indicum protected mice against tonic convulsions induced by Maximal electroshock.