Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2011
  • Volume: 4
  • Issue: 12

Exploring the Protective Role of Water Extract of Spirulina platensis on Flutamide-Induced Lipid Peroxidation Using 4-Hydroxy Nonenal and Nitric Oxide as Model Markers

  • Author:
  • Supratim Ray
  • Total Page Count: 4
  • Page Number: 1857 to 1860

Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy and Allied Health Sciences, Bidhannagar, Durgapur, 713 206, India

*Corresponding author: supratimray_in@yahoo.co.in

Abstract

This in vitro study was designed with an aim to evaluate free radical scavenging activity of water extract of Spirulina platensis on flutamide-induced lipid peroxidation using 4-hydroxy nonenal and nitric oxide as model markers. In this study goat liver has been used as liver source. The results suggest that flutamide could induce lipid peroxidation to a significant extent and it was also found that water extract of the Spirulina platensis has the ability to suppress the flutamide-induced toxicity.

Keywords

Flutamide, Spirulina platensis, lipid peroxidation, 4-hydroxy-2-nonenal, nitric oxide