The nasal mucosa deliberated as a potential administration route. Because of large surface area, porous endothelial membrane, rapid blood flow, first pass metabolism avoidance and quick accebility the drug absorption has been faster and also higher. Protein and peptides, low molecular weight polar molecules antiparkinson's drugs and macromolecular polysaccharides. The major hurdle in nasal route of administration is the poor contact of formulation with mucosa of nose. But using absorption enhancer and mucoadhesive polymer the increase in residence time of drug in nasal mucosa. Many researchers became interested in the nasal route for the systemic delivery of medication due to high degree of vascularization and permeability.
