1Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G.Nagara-571448, Mandya
2Principal, Mayani College of Pharmacy, Mayani-415102, Tal: Khatav, Dist: Satara
*Corresponding Author E-mail: chetanbhalgat2004@yahoo.co.in
Online published on 3 April, 2013.
The 3-(1-benzofuran-2-yl)-5-(substituted phenyl) isoxazole have been synthesized by the reaction of Benzofuran chalcone with hydroxylamine hydrochloride in presence of sodium acetate in ethanol. All the compounds were synthesized by conventional method and characterized by IR, 1H NMR and mass spectral data. The new synthesized derivatives I1-I7 was evaluated for in vitro cytotoxic activity on HeLa cell lines. Compounds I1-I7 was scheduled for evaluation against full panel of human cervical cancer cell lines at the minimum seven concentrations at two fold dilutions.
Benzofuran, isoxazole, chalcone, conventional, cytotoxic activity
