Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2011
  • Volume: 4
  • Issue: 2

Design, Synthesis and Biological Evaluation of Methyl-2-(2-(Arylideneamino) Oxazol-4-Ylamino) Benzoxazole-5-Carboxylate Derivatives as New Antiinflammatory Agents

  • Author:
  • Nageshwar Rao Chilumula1, Srinivas Ampati2, Rajyalaxmi Gudipati2, Sarangapani Manda2, Dayakar Gaday1,
  • Total Page Count: 6
  • Page Number: 302 to 307

1Departmet of Chemistry, Kakatiya University, Warangal, A.P-India, 506009

2University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P.-India, 506009

*Corresponding Author E-mail: profgdayakar@gmail.com

Online published on 3 April, 2013.

Abstract

A series of novel methyl-2-(arylideneamino)oxazol-4ylamino)benzoxazole-5-carboxylate derivatives synthesized. The structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analysis. Compounds were evaluated for their anti-inflammatory activity. Derivatives VIId and VIIe exhibited very good and almost equal anti-inflammatory activity in carrageenan-induced rat paw edema method compared with the standard drug Diclofenac Sodium.

Keywords

Benzoxazole derivatives, IR, 1H NMR and Mass spectroscopy, methyl-2-(arylideneamino)oxazol-4ylamino) benzoxazole -5-carboxylate, anti inflammatory