1Division of Medicinal Chemistry, Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow, Pin-226002, Uttar Pradesh, India
2Division of Biotechnology (M.S. Pharm), National Institute of Pharmaceutical Edu. and Research (NIPER), Ahmedabad, C/O B. V. Patel PERD Centre, SG Highway, Thaltej, Ahmedabad, Pin-380054, Gujarat; India
*Corresponding Author E-mail: kumudgupta99@gmail.com
Online published on 3 April, 2013.
Ten Acyl hydrazine derivatives of ciprofloxacin were synthesized and evaluated for antibacterial activity in – vitro against Gram positive and Gram negative organisms. Among the synthesized compounds KSS3, KSS5, KSS7, KSS8, KSS9, were found to be the most active compounds with an MIC of 0.075 μg/ml against S. aureus, B. bronchiseptica, S. epidermis, E. coli, P. aeuroginosa and K. pneumoniae. These compounds were found to be 53.33 times more active as ciprofloxacin where as other five compounds KSS1, KSS2, KSS4, KSS6 and KSS10, were found to be 1.33 times more active as ciprofloxacin with an MIC of 3 μg/ml. The results demonstrate the potential and importance of developing new quinolone derivatives against bacterial infection.
Fluoroquinolones, Schiff base, Acyl hydrazine, Antibacterial activity
