Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives

Ten Acyl hydrazine derivatives of ciprofloxacin were synthesized and evaluated for antibacterial activity in – vitro against Gram positive and Gram negative organisms. Among the synthesized compounds KSS₃, KSS₅, KSS₇, KSS₈, KSS₉, were found to be the most active compounds with an MIC of 0.075 μg/ml against S. aureus, B. bronchiseptica, S. epidermis, E. coli, P. aeuroginosa and K. pneumoniae. These compounds were found to be 53.33 times more active as ciprofloxacin where as other five compounds KSS₁, KSS₂, KSS₄, KSS₆ and KSS₁₀, were found to be 1.33 times more active as ciprofloxacin with an MIC of 3 μg/ml. The results demonstrate the potential and importance of developing new quinolone derivatives against bacterial infection.