1BA&KR College of Pharmacy, Doddavarapadu, Ongole, Andhra Pradesh, INDIA
2Vagdevi College of Pharmacy, Nellore, Andhra Pradesh, INDIA
3MRR College of Pharmacy, Nandigama, Andhra Pradesh, INDIA
4Sri Vani College of Pharmacy, Vijayawada, Andhra Pradesh, INDIA
*Corresponding Author E-mail: shaikharunrasheed@gmail.com
Online published on 3 April, 2013.
The simple, accurate and precise methods for simultaneous estimation of Rabeprazole sodium and Itopride hydrochloride in capsule dosage form by Spectrophotometric method, the absorbance values at 284nm and 258nm for Rabeprazole sodium and Itopride hydrochloride. Beer-Lambert's law over the concentration rang for Rabeprazole sodium was 1-5ug/ml and Itopride hydrochloride 7.5–37.5ug/ml, with r values between 0.9994–0.9998.The percentage recovery value was found to be 100%, it indicates there is no interferences of additives with Rabeprazole and Itopride present in capsule dosage form. The method has been validated as per ICH guidelines and %RSD value NLT 2(<2%) was found. The proposed method was successfully applied for estimation of Rabeprazole and Itopride in combined capsules dosages formulation.
Uv-Spectrophotometry, Rabeprazole sodium, Itopride hydrochloride
