Evaluation of Analgesic Activity of Leaves Extracts of Feronia limonia in Experimental Animal Models.

Feronia limonia (Rutaceae) commonly known as wood apple is a wild growing medicinal plant distributed throughout India. The various part of the plant is practiced in various traditional systems of medicine around the world and popular among the various ethnic groups for the treatment of variety of ailments. Following the various traditional claims on use of Feronia limonia in curing number of diseases, considerable efforts have been made by researchers to verify its utility through scientific pharmacological screenings. It is widely used in Indian folk medicine for the treatment of diarrhoea, dysentery and hiccough etc. Leaves, bark, roots and fruit pulp are all used against snake bite. It also has anti-microbial, hepatoprotective, anti-diabetic, anti-ulcer, anti-malarial activities. The successive solvent extraction of powdered leaves was done of Feronia limonia with chloroform and ethanol. The peripheral analgesic activity of both extracts of Feronia limonia (100 and 200 mg/kg) was studied using acetic acid-induced writhing in mice. The central analgesic activity of both extracts of Feronia limonia (100 and 200 mg/kg) was studied using Eddy's hot plate. EEFL (200 mg/kg) significantly decreased the writhing movements in acetic acid-induced writhing test. EEFL(200 mg/kg) significantly increased the reaction time in hot plate test.