In vitro Evaluation of Isosorbide Dinitrate Calcium Alginate Controlled Drug Delivery Beads and Its Modified Form Using Different Cross-Linking Agents

Isosorbide dinitrate, a vasodilator is the drug incorporated into calcium alginate beads by encapsulation procedure with polymer sodium alginate and cross-linking agents (Gluteraldehyde and Formaldehye). The Formulations were tested for entrapment efficiency and drug release in various buffered medium. The beads containing formaldehyde as the cross-linking agent was found with maximum drug release of 85% in pH 7.5 and all the three formulations had efficient drug release in basic pH. Effect of pH in release of drug from polymer.