Formulation and Evaluation of Iontophoretic Transdermal Delivery of Atorvastatin Calcium

The objective of the study was to investigate the iontophoresis transdermal transport of atorvastatin calcium and compared to the passive transport. The atorvastatin calcium transdermal patches were prepared by solvent casting method employing sodium alginate, HPMC K4M and sodium CMC as a polymer and glycerin used as a plasticizer. The compatibility study of drug with the excipients was determined by I.R. Spectroscopy (FTIR). Absorption of drug was estimated using phosphate buffer solution of pH 7.4 as blank in UV spectrophotometer at 245nm. The influence of different evaluation parameters of physical appearance, uniformity of weight, film thickness uniformity, folding endurance, percentage moisture loss, percentage moisture absorption, drug content uniformity and viscosity of formulation with various polymer and drug matrix were investigated. SEM image has taken for to determine surface morphology of particles in matrices patches. The in vitro drug permeation study was done with rat abdominal skin by using Modified Franz Diffusion Cell. The percentage drug release from sodium alginate (F1) film was more as compared with other formulations and also reported that the delivery is proportional to applied current.