1V.V.Pura Institute of Pharmaceutical Sciences, Bangalore
2A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Andhra Pradesh
3Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh
4Rahul Institute of Pharmaceutical Sciences and Research, Chirala, A.P.
5College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P.
*Corresponding Author E-mail: rameshvips@rediffmail.com
Online published on 3 April, 2013.
Four simple and sensitive spectrophotometric methods (A – D) for the assay of naratriptan hydrochloride in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference.
