Research Journal of Pharmacy and Technology

Present in-vivo study was carried out to evaluate the antidiabetic, lipid lowering and antioxidant activity of methanolic extract of Lawsonia inermis leaves in alloxan induced diabetic rats using glibenclamide (10mg/kg) as standard drug. Oral administration of methanolic extract of Lawsonia inermis leaves (600mg/kg body weight) for 14 days resulted in significant decrease in fasting blood glucose level (34.33%), serum triglycerides (43.35%), total cholesterol (34.18%), low density lipoprotein (11.05%), GOT (42.89%), and GPT (28.09%) with simultaneous increase in serum high density lipoprotein (50.48%) and serum glucokinase (208.75%). Further the methanolic extract of Lawsonia inermis leaves inhibited the generation of Malondialdehyd (TBARS) level (34.34%) in alloxan induced diabetic rats. The results of the present study demonstrate antidiabetic, lipid lowering and antioxidant activities in methanolic extract of Lawsonia inermis leaves, which could help in prevention of diabetic hyperlipedemia and related diseases.