Hepatoprotective Activity of Butea monosperma bark on Liver Damage Caused by Paracetamol in Rats.

The objective of this study was to investigate the hepatoprotective activity of Butea monosperma bark, against paracetamol induced hepatotoxicity. The Bark was dried in shade, powdered and Extracted with ethanol. Preliminary phytochemical analysis show the presence of phenolic compound and flavanoids. The ethanolic extract of Butea monosperma bark (EEBM) showed a significant dose dependent (250 mg and 500 mg/kg p.o.) protective effect. The degree of protection was measured by using biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total protein (TP), albumin(Alb) and total bilirubin (TB). The effects of EEBM was comparable to that of standard drug, Silymarin (25mg/kg). All the test drugs were administered orally by suspending in 0.5% of Tween 40 suspension.