Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation

Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist with antiemetic properties. Various methods for analysis of same are available but are time consuming and expensive. Various simultaneous method of Domperidone with another drug is available. Here we have developed new, precise, simple spectrophotometric method for estimation of Domperidone from bulk. Medium prepared were selected 0.1 N HCl having pH 1.2. It showed absorption maxima at 284nm.This method were validated according to ICH guidelines. The drug obeyed Beers law and showed good correlation. The linearity was observed between 0–20 mcg/mL. There was no significant difference in the intraday and interday analysis of Domperidone determined. The results of analysis were validated with respect to recovery, linearity; Limit of detection and limit of quantitation were found to be satisfactory.