Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablet. In the present study, an attempt has been made to prepare fast dissolving tablets of the drug telmisartan using meglumine as an organic base. Telmisartan, in the presence of acidic pH rapidly ionized and which leads to decrease absorption. This problem can be overcome by using meglumine. Meglumine is an organic base used as a pH-adjusting agent. Fast dissolving tablets of telmisartan were prepared by direct compression method using three superdisintegrants crospovidone, sodium starch glycolate and croscarmellose sodium in different concentrations. Ten formulations having superdisintegrants at different concentration levels were prepared to assess their efficiency and critical concentration level. Different types of evaluation parameters were used. Tablets containing crospovidone showed superior organoleptic properties, along with excellent in vitro and a vivo dispersion time and drug release, as compared to other formulations.
Telmisartan, Meglumine, Aspartame, Croscarmellose Sodium, Sodium starch glycolate, Crospovidone
