Formulation and Evaluation of Chlorpheniramine Maleate from Methyl Cellulose Patches

Administration of drugs through skin has received great attention through the last decade. Hence this study aims to formulate an anti-histaminic drug – chlorpheniramine maleate (CPM) as transdermal patch using methyl cellulose -a bioadhesive polymer with dibutylphthalate (DBP) as plasticizer. Patches were prepared through solvent evaporation method, subjected for various evaluations including in vitro dissolution and in vitro permeation. The above evaluations of transdermal patches promises that CPM can be developed successfully as transdermal patches as an alternative route of administration fulfilling the objectives of this research work.