In Vivo Efficacy Study of Aceclofenac Gel Containing Linseed Oil and Ginger Oleoresin

Aceclofenac is a Non-Steroidal Anti-Inflammatory Drug (NSAID), used in the treatment of inflammation and degenerative disorder of the musculoskeletal system. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, dysmenorrheal, acute lumbago, musculoskeletal trauma and gonalgia (Knee pain). Aceclofenac is well tolerated, with most adverse events being minor and reversible and affecting mainly the G.I system. Most common events include dyspepsia, abdominal pain, nausea, ulcerative stomatitis and pancreatitis. In present study anti inflammatory activity of aceclofanac gel containing linseed oil and ginger oleoresin was checked by using Albino rats (Strain Wistar). It was found that aceclofanac gel containing 3% linseed oil, 1.5% ginger oleoresin and 10% methyl salicylate shows 81.16% edema inhibition in 3^rd hour as compare to marketed Nusaid gel which shows 76.74% edema inhibition.