Enhancement of Nateglinide Solubility and Dissolution Rate

The aim of this study was to investigate the physicochemical properties of Nateglinide in inclusion complex. The phase solubility behavior of Nateglinide in presence of various concentrations of β-CD in pH 7.4 buffers was obtained at 37°C. The solubility of Nateglinide increased with increasing the concentration of β-CD. The inclusion complex of Nateglinide with β-CD were prepared at in various ratios (C1-1:1 Nateglinide: β-CD, C2-1:2 Nateglinide: β-CD, C3 1:3 Nateglinide: β-CD) using Kneading method. Prepared inclusion complexes were evaluated by FT-IR, LC-MS, DSC, NMR and SEM. The FT-IR spectroscopic studies showed the stability of Nateglinide and absence of welldefined Nateglinide-β-CD interaction. Among all prepared inclusion complexes, C3 showed the best release pattern.