Ofloxacin Loaded Lipid colloidal carrier (Liposphere) for Treatment of Bacterial Infections

Aim of the present research was to investigate the influence of formulation parameters on production of ofloxacin loaded lipid colloidal carriers (lipospheres). Lipospheres of ofloxacin were formulated by melt dispersion technique using cetyl alcohol in different drug–lipid ratios. PVA (surfactant) and pectin (co-surfactant and stabilizer) were used. Mean particle size, percentage encapsulation efficiency and drug release at end of 8hr were considered. The optimized formulation containing the lipophilic drug displayed satisfactory encapsulation efficiency 73% and a mean diameter of 62 μm. The formulated lipospheres were characterized by morphological characters such as Photomicroscope, Scanning electron microscope, entrapment efficiency, percentage of yield. In-vitro drug release, which showing that all the formulations were released the drug in controlled manner.