Development and Evaluation of Lisinopril Transdermal Patches

The present study was carried out to develop matrix type transdermal drug delivery system (TDDS) of Lisinopril using a combination of polymers i.e.,Eudragit RS100(ERS100),EudragitRL100(ERL100) and polyvinylpyrrolidone (PVP). Propylene glycol was used as plasticiser and dimethylsulphoxide (DMSO) as penetration enhancer. IR and TLC studies were performed to follow drug carrier interactions. TDDS were prepared by solvent casting method employing methanol-water as solvent system. The physicochemical parameters like weight variation, thickness, folding endurance, drug content, tensile strength and stability were evaluated. An in vitro study was carried out using Modified Keshary Chien permeation cell. In vitro permeation profile of the formulated patches showed that formulations T4 (ERL100: PVP 2:3) and T9 (ERS100: PVP 2:3) showed highest permeation. The release of drug from all the formulations followed the diffusion controlled Higuchi Model and zero order release kinetics. The formulations were most stable at room temperature.