1Department of Pharmaceutical Biotechnology, QIS College of Pharmacy, Vengamukkapalam, Ongole, Andhra Pradesh, India-523 272
2Department of Pharmaceutical Biotechnology, Ultra college of Pharmacy, Madurai, India-625 020
*Corresponding Author E-mail: rssrmcp@yahoo.co.in
Online published on 3 April, 2013.
L-asparaginase is an important chemotherapeutic agent used for the treatment of a variety of lymphoproliferative disorders, lymphomas and acute lymphoblastic leukemia. In recent years, the use of L-asparaginase in the treatment of leukemia and other lymphoproliferative disorders has expanded immensely. In view of the potential applications of L-Asparaginase and the need for development of economical methods for improved enzyme production with an overall aim of reducing the cost of the industrial process, solid state fermentation (SSF) can serve as an excellent alternative for increasing enzyme yields. Hence present investigation was aimed at exploring the synthetic ability of L-Asparaginase from Pectobacterium carotovorum (MTCC 1428) and Bacillus circulans (MTCC 490) by providing suitable synthetic mediums.
L-asparaginase, Pectobacterium carotovorum, Bacillus circulans, solid state fermentation
