Comparative Spectrophotometric Analysis of Simultaneous Estimation of Esomeprazole and Domperidone in Tablet Dosage Form

Three simple, accurate and economical methods have been developed for the estimation of esomeprazole and domperidone in tablet dosage form. First method is based on the simultaneous equations, wavelengths selected for analysis were 301.0 nm (λ_max of esomeprazole) and 287.5 nm (λ_max of domperidone), respectively, in methanol. Second method is Q-analysis method, based on absorbance ratio at two selected wavelengths 291.0 nm (iso-absorptive point) and 301 nm (λ_max of esomeprazole). Third method is first order derivative spectroscopy using 301.5 nm (zero cross for esomeprazole) and 286.5 nm (zero cross for domperidone). The linearity was obtained in the concentration range of 530 μg/ml and 4–20 μg/ml for esomeprazole and domperidone, respectively. The results of the analysis have been validated statistically and by recovery studies.