Microwave Assisted Rapid and Efficient Synthesis and Screening of Halogenated Anilin-yl-Substituted Thiazolidin-4-One Derivatives for Antimicrobial Activities.

3-chloro-4-fluoro phenyl hydrazine was synthesized from 3-chloro 4-fluoro aniline in the presence of hydrazine hydrate. Compound upon treatment with substituted aromatic aldehydes yielded some Schiff's bases(2,2’-disubstituted-1(3-chloro-4-fluoro)phenyl hydrazones)which upon treatment with mercapto acetic acid afforded some disubstituted thiazolidin-4-ones. These thiazolidin-4-ones were treated with some substituted aromatic aldehydes to arrive at 5-arylidene derivatives of substituted thiazolidin-4-ones. The compounds were structurally confirmed by IR,¹H NMR and Mass spectral data. The synthesized compounds were screened for their antibacterial, antifungal and antitubercular activities.