Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2011
  • Volume: 4
  • Issue: 9

Visible Spectrophotometric Determination of Amlodipine Besylate in Bulk Drug and Tablet Dosage Form

  • Author:
  • Aswini G. Lakshmi1,, D. Dhachinamoorthi2, J.V.L.N. Seshagiri Rao3, C.H. Prasada Rao2, M.L. Surekha1
  • Total Page Count: 4
  • Page Number: 1432 to 1435

1Dept. of Pharmaceutical Analysis, Vagdevi College of Pharmacy, Gurazala-522415

2Dept. of Pharmaceutical Analysis, QIS College of Pharmacy, Ongole -523272

3Dept. of Pharmaceutical Analysis, University College of Pharmaceutical Sciences, Visakhapatnam -530003

*Corresponding Author E-mail: aswinipharmagl@gmail.com

Abstract

A simple visible spectrophotometric method has been developed for the estimation of amlodipine besylate in bulk and tablet dosage form. This method is based on the reaction between amlodipine besylate and potassium hydroxide in presence of dimethyl sulphoxide. The yellow chromogen obtained has absorbance maxima at 456nm. It obeys Beer's law in the concentration range of 3–30 mcg/ml. This method was validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the method is reproducible and selective for the estimation of said drug.

Keywords

Visible spectrophotometry, Amlodipine besylate, Potassium hydroxide, Dimethyl sulphoxide, Validation