Anti-Hemorrhoidal Activity of Leaf Extract of Adenia lobata (Jacq.) Engl. (Passifloraceae)

Next to modern therapeutic, many plants resulting from the African traditional pharmacopeia are used by the traditional healers as anti-hemorrhoidal remedies. The aim of this study was to evaluate the anti-hemorrhoidal activity of leaves of Adenia lobata. This work has focused on the inflammatory aspect of the hemorrhoid. Induction of inflammation was made with kaolin mixed with arabic gum. Solutions of A. lobata leaves used with preventive measure delay the inflammatory process of hemorrhoidal disease and for curative cure hemorrhoidal inflammation. Also, the anti-inflammatory activity observed is due to flavonoids present in leaves of A. lobata. Preparation of solutions with cool water is more effective than that carried out with the hot water which denatures the active ingredients of the remedy. At the doses used, this remedy is deprived of acute toxicity and can be taken safety by patients. A six times higher solution concentration than that of the traditional healer gives a similar anti-inflammatory response to it. Thus, there is a minimum concentration of A. lobata leaves solutions from which the anti-inflammatory effect is maximal. The anti-hemorrhoidal action of leaves of A. lobata was established and tests on veinotonic aspect are in progress.