Hydrotropic Solubilistion Technique of Metaxalone by U.V. Spectroscopy and First Order Derivative Spectroscopy

Solubility of various poorly water-soluble drugs can be increased by the use of hydrotropic solubilisation technique. In the following investigation, solution of 0.5 M sodium acetate was employed as solubilising agent to solubilise poorly water soluble drug. Metaxalone showed absorbance maxima at 278nm. Beer's law is obeyed in the concentration range of 40–240μg/mL in two methods. Method-A UV Spectroscopy which involves measurement of absorbance maxima. Method– B Derivative spectroscopy involves the derivatisation of the primary absorption spectra for the first order. The amplitude (DL) of the long wave peak satellite of the first order curve was measured in mm. The results of analysis and the recovery studies which were validated statistically were found to be satisfactory. Presence of sodium acetate did not interfere in the analysis of Metaxalone and therefore both methods are accurate providing additional advantages of being cost effective and environmental friendly.