Synthesis and Study of Fluorimetric Properties of Lisinopril Derivatives

Lisinopril is antihypertensive drug acts by Inhibition of Ace enzyme. Lisinopril derivatives synthesized by coupling or condensation reactions with fluorophores or reagents which produce fluorescent compounds. The fluorescent derivatives of Lisinopril are confirmed by the spectral data like IR, NMR, physical properties such as MP, Rf Value, solubility, and chemical properties. The intensity of fluorescence is higher for Ia, IIa, IIIa, IVa and low for Va, VIa and the derivatives VIIa show no fluorescent properties. The derivatives show different fluorescent property depending upon the reagents coupled. The synthesized products are measured for their fluorescent properties which can be used for identification and estimation of drug.