1University Institute of Pharmacy, Baba Farid University of Health Sciences, Faridkot.
2Dept. of Applied Chemistry, S.B.S. College of Engineering and Technology, Ferozepur.
3Swift School of Pharmacy, Ghaggar Sarai, Rajpura.
* Corresponding author: arunkaura70@rediffmail.com
Online published on 12 February, 2013.
In this report, synthesis and antimicrobial study of some Schiff bases and β-lactam derivatives has been reported. The synthesized Schiff bases and β-lactam derivatives were characterized by spectral data, including 1H-NMR, IR, Mass and Elemental analyses. All the compounds were screened for their in vitro antibacterial activity against two Gram +ve (Staphylococcus aureus, Bacillus subtilis) and two Gram –ve (Escherichia coli, Pseudomonas aeruginosa) bacterial strains by agar-well diffusion method. The Schiff bases were found to exhibit either no or low to moderate activity against one or more bacterial species. On contrary, all the -lactam derivatives exhibited varied activity against different bacteria.
Schiff bases, β-lactams, spectral data, antibacterial activity and bacterial strains
