In vitro anticancer activity of Ethanolic and Aqueous Extracts of Peristrophe bivalvis Merrill.

In present study in vitro anticancer activity of ethanolic and aqueous extracts of leaves and stems of Peristrophe bivalvis Merrill was evaluated. In vitro anticancer activity was assayed by tryphan blue dye exclusion method and brine shrimp lethality bioassay method. Extracts were found to be cytotoxic in dose dependent manner in both methods. Ethanolic extract was found to be potent than aqueous extract. Leaves showed more significant anticancer activity as compared to stems. The CTC₅₀ of ethanolic extract of leaves was found to be 175.25±12.34 μg/ml in EAC cell lines. The LC₅₀ of ethanolic extract of leaves was176.49±7.43 μg/ml. It indicated that Peristrophe bivalvis Merrill has potential to prevent cancer in a dose dependent manner.