Formulation and Evaluation of Sustained Release of Ofloxacin Ocular Inserts

Ocuserts is the new drug-delivery systems which are designed in such a way that they release the drug at the predetermined rate thus eliminating the frequent administration of the drug. The aim of the present study was to develop an ophthalmic insert of Ofloxacin and evaluate for sustained ocular delivery of drug. The seven ocuserts (F1 to F7) were prepared using polyvinyl alcohol in different concentration by solvent casting technique. The prepared ocuserts were evaluated for weight variation, content uniformity, swelling index, surface pH, assay, % moisture absorption, % moisture loss and assessment of drug release. According to the results, 100% of drug was released from the F5 over a period of 16 h. The data obtained for this study suggest that ocular inserts of Ofloxacin are promising for sustained drug delivery, which can reduce dosing frequency.