Enhancement of Dissolution Rate of Cefpodoxime Proxetil by Using Solid Dispersion and Cogrinding Approaches

Cefpodoxime proxetil (CP) have the poor aqueous solubility due to its metabolic degradation in lumen, hence dissolution is the rate limiting step for poorly soluble drugs. In present study, in order to enhance the drug dissolution rate of CP by solid dispersion using carriers such as polyethylene glycol 6000, polyvinylpyrrolidine K30 and cogrinding mixtures with carriers such as sodium starch glycolate, croscarmellose sodium and polyplasdone XL by varying the drug to carrier ratios. The dissolution rate of CP from solid dispersions and co-grinding mixtures were measured and found to be around 55–70%. The formulated solid dispersion and co-grinding mixture was characterized by FT-IR spectroscopy, DSC, SEM and X-Ray diffraction method. In-vitro dissolution rate of CP from the solid dispersion with PVP K30 at the ratio of 1:4 and co-grinding mixtures with Croscarmellose Sodium (CCS) at the ratio of 1:4 was significantly greater compare to that of the pure drug. The dissolution rate of the drug was affected by nature and the amount of polymer used. FT-IR spectroscopy demonstrated no detectable interaction between the drug and carrier. The DSC and XRD studies indicated amorphous state of the CP from solid dispersion and co-grinding mixtures. The SEM images have shown the formation of effective solid dispersion and co-grinding mixtures, since well defined changes in the surface nature of CP. Thus, solid dispersion and co-grounding approaches can be successfully used for the enhancement of dissolution profile of the drug CP.