Formulation and Evaluation of Candesartan Niosomal Suspension

Objective of the present research work is to develop the liquid dosage form (niosomal suspension) of candesartan. Niosomes have been prepared using two different non ionic surfactants by thin film hydration technique and are characterized for size, shape, entrapment efficiency, invitro drug release and stability. SEM studies have been carried out which shown that the niosomes are spherical in shape with smooth surface. All the vesicles appeared in the size range of 8.1– 11.3μm. % entrapment efficiency has been carried out by dialysis method and the results are confirmed with centrifugation method. Niosomes prepared using spans showed good results than the niosomes prepared using tweens. Among all formulations, FS603 has shown highest entrapment efficiency [71.2%]. Diffusion studies were carried out to study the drug release pattern from all formulations and are revealed that increase in the concentration of surfactant decreases the drug release from niosomes, in all formulations prepared using spans and tweens. Among all formulations, FS603 has shown better sustained release, which is desirable for enhancing the bioavailability. Hence, FS603 has been optimized as best formulation and carried stability studies as per ICH guidelines and are revealed that the niosomes are stable for long time at refrigerated temperature.