A simple, sensitive, precise, accurate, rapid, and reproducibility reverse phase high performance liquid chromatography procedure is development for simultaneous determination of lisinopril and amlodipin besilate in solid dosage form the mobile phase use was a combination of acetonitril: buffer (35:65v/v) and the ph was adjusted 7.0 to 0.1 by addition of triethanolamine the detection of solid dosage form tablet was carried out at 266 nm. and flow rate was employed 1ml/min. linearity was obtain in the concentration of range 50–500 of lisinopril and 5–50 of amlodipin with coordination of 0.9999 and 0.9999 the result of analysis were validation statically and recovery study conform the accuracy of proposed method.
RP-HPLC, Amlodipin, Validation
