An overview on Combinatorial Chemistry

Combinatorial chemistry is a new methodology by which we can simultaneously synthesize a large number of possible and defined compounds that could be formed from a number of building blocks (starting materials) which are screened for pharmacological activity. This combinatorial chemistry technique has been explored as an alternative to conventional approaches for the synthesis of compounds in the drug discovery process. The combinatorial techniques are developed in accordance to the increased advancements in the screening methods such as high throughput screening. This article also tries to present pros and cons the combinatorial chemistry, some of the advances made in recent years and their applications and screening methods for the combinatorial libraries