Development of UV Spectrophotometric Method of Meclizine Hydrochloride in Bulk and Pharmaceutical Formulation.

Three simple, precise and economical UV methods have been developed for estimation of Meclizine hydrochloride in single component. Meclizine hydrochloride has the absorbance maxima in zero order spectra is 230nm (Method A). Method B applied was First order derivative for the analysis of Meclizine hydrochloride at 238.5.nm. Method C applied was area under curve in the wavelength range of 234–228 nm. Drug followed Beer-Lambert's law in the concentration range of 5–35μg/ml for zero order, 10-6 μg/ml for area under curve method and first order derivative spectrum. The percentage recovery of Meclizine hydrochloride ranged from 98.05 to 101.075 in pharmaceutical dosage form results of analysis were validated statistically and by recovery study.