A Review: Biological Importance of Mercapto Substituted 1,2,4-triazole Derivatives

Compounds containing 1,2,4-triazole moiety find wide range of applications and substituted 1,2,4-triazoles are becoming more prevalent in functional materials that are at the cutting edge of new technology. The biological activities of 1,2,4-triazole derivatives are well documented and important discoveries in this area are continued, though the electron donor and coordinating ability of 1,2,4-triazoles has also seen an increase in their use as ligands, functional polymers, and industrial coatings. 1,2,4-triazole has shown its importance as antimicrobial, antiinflammatory, hypoglycemic, antidepressant, antitubercular, analgesic, antimalarial and anticancer agents. This article is based on different pharmacological activities exhibited by the various compounds containing mercapto and/or thione substituted 1,2,4-triazole heterocyclic ring systems. This review highlighted the basic pharmacophoric requirements for the successful development in the designing of novel antibacterial, antifungal, antitubercular, and antiinflammatory mercapto triazole agents.