Effects of Strychnos potatorum Linn. seeds on Triton WR 1339 Induced Hyperlipidemia in Rats

We investigated the antihyperlipidemic activity of Strychnos potatorum seeds. The current study was undertaken to assess the hypolipidemic, hypocholesterolemic and hypotriglyceridemic potential of the seeds using triton WR-1339 (Tyloxapol) induced hyperlipidemia in rats. The animals were divided into five groups: control, hyperlipidemic, hyperlipidemic plus Atorvastatin, hyperlipidemic plus Strychnos potatorum seed powder 100mg/kg and Strychnos potatorum seed powder 200mg/kg. Hyperlipidemia was induced by single intraperitoneal injection of triton WR 1339 at a dose of 400mg/kg. Intragastric administration of seed powder significantly (p<0.05) decreased serum total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol levels in rats in dose dependent and time dependent manner compared to hyperlipidemic group. Thus, the findings of the investigation suggest that Strychnos potatorum seeds exhibited quite competitive potential when compared with reference drug Atorvastatin against experimentally induced hyperlipidemia.