Formulation and Evaluation of Gastro-Retentive Drug Delivery System of Some Selected Drugs

Itopride hydrochloride is a novel gastroprokinetic, widely absorbed from the stomach and upper part of the small intestine and absorption becomes less as the drug passes beyond this. The bioavailability can be improved by making the drug completely absorbed in the stomach and upper part of the small intestine. It has a half life of 5h2. The short half life of Itopride hydrochloride necessitates frequent administration. Therefore it is highly desirable to have a controlled release dosage form for Itopride hydrochloride. The objective of this present investigation was to formulate gastro-retentive tablets of itopride hydrochloride using a gas generating agent. We attempted to formulate to retain the matrix tablet in the stomach and subsequently to provide delivery of the drug over the period of time of GRT.