Protective effect of Pseudarthria viscida (L.) against Paracetamol induced hepatotoxicity

In this study we have evaluated the hepatoprotective activity of methanolic extract of Dasamoola plant Pseudarthria viscida L. (PVM) in rats toxicated with high dose of paracetamol. Animals were treated with two concentrations of PVM (200 mg/kg and 400 mg/kg) for seven consecutive days. After 24 hrs of paracetamol treatment animals were sacrificed; liver tissue and blood samples were collected. The level of protection was evaluated by measuring the serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin levels and superoxide dismutase (SOD), glutathione peroxidase (GPX), reduced glutathione (GSH) and malondialdehyde (MDA) levels in liver tissue homogenates. Levels of serum GOT, GPT, ALP and bilirubin were got reduced in PVM treated animals. PVM treatment was also found to be effective in plummeting paracetamol induced oxidative stress.