Spectrophotometric Method for Simultaneous Estimation of Olmesartan Medoxomil and Amlodipine Besylate in Pharmaceutical Preparations

Simple spectrophotometric method has been developed for simultaneous estimation of Olmesartan Medoxomil and Amlodipine Besylate in combined dosage form. The method employed simultaneous equation method for analysis using methanol as a solvent. The two wavelengths 256 nm and 364 nm were selected for estimation of Olmesartan Medoxomil and Amlodipine Besylate respectively. Linearity was observed in the concentration range of 2–20 μg/mL for both the drugs Olmesartan Medoxomil and Amlodipine Besylate. The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents.