Development of Matrix Type Transdermal Patches of Granisetron Hydrochloride: Physicochemical and in-Vitro Characterization

Transdermal patches of granisetron hydrochloride with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, Eudragit RL100 and Eudragit RS100 were used in rate controlling membrane to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thicknesses, tensile strength, content uniformity, folding endurance were uniform in prepared batches. In vitro permeation studies were performed using a Franz diffusion cell across hairless guinea pig skin. The effects of non-ionic surfactants Tween 80 and Span 80 on drug permeation were studied. The non--ionic surfactants Span 80 exhibiting better enhancement relative to Tween 80