Recent Advances in Coupling Technology in Analysis of Natural Product

Natural products have been the single most productive source of leads the development of drugs. The hyphenated technique is developed from the coupling of separation technique and on line spectroscopic detection technology. There is improvement in hyphenated r the last two decades have significantly broadened their application in the analysis of biomaterials especially natural products. In these article recent advances in the application of various hyphenated techniques e.g. LC-IR, LC-NMR, LC-MS, HPLC-NMR-MS, LC-ESI-MS, UPLC-MS, in the context of pre-isolation analysis of crud extract or fraction from various natural sources, isolation and online detection of natural products, chemotaxonomic studies, chemical fingerprinting, quality control of herbal products, dereplication of natural products and metabolomic studies are discussed here.