Synthesis and Antimicrobial Evaluation of [(1H-benzotriazol-1-ylacetyl) amino] Acetic Acid Derivatives

Five novel [(1H-benzotriazol-1-ylacetyl)amino]acetic acid derivatives were synthesized by substituting corresponding amino acids on a reaction intermediate 1H-benzotriazol-1-ylacetyl chloride. The derivatives were characterized by physical, chemical parameters, TLC and spectral data. Synthesized derivatives from Ib to Vb were screened for anti microbial activity against, S. Aureus, B. Subtilis, E. coli, S. typhi, C Albicanse, A Niger. MIC was measured against norfloxacine and ketoconazole. Present study confirms the synthesized derivatives endowed with effective antimicrobial activities.